Membranous nephropathy (MN) is an immune-mediated disease caused by circulating antibodies (ab) directed against endogenous or planted antigens on the podocyte surface. The major target antigen in patients with MN is phospholipase A2 receptor 1 (PLA2R1), accounting for 70%-75% of patients.1 In the past few years, a large number of potential target antigens have been reported in patients with MN.2 The knowledge of these antigens is of fundamental importance, because it may direct further diagnostic steps and treatment of patients.
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